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黄河

姓 名 黄河 性 别 职 称 研究员
学 历 博士 电 话 传 真
电子邮件 hhuang@simm.ac.cn 个人主页 主页链接 专家类别
职 务 党委书记
通讯地址 烟台市牟平区滨海东路198号
个人简介

黄河,研究员,博士生导师,课题组长。主要从事基于蛋白质组学的化学生物学研究,包括蛋白质动态修饰通路的发现与调控机制阐释,以及基于蛋白质动态修饰的新靶标发现和药物研发。代表性研究成果:(1)系统地鉴定了赖氨酸?-羟基丁酰化修饰的调控酶,绘制了哺乳动物细胞的?-羟基丁酰化修饰图谱,阐释了该修饰耦合代谢物与多种细胞进程的新机制、新途径;(2)阐明了一种小檗碱衍生物发挥降血脂作用的新靶点及其独特新机制,为降血脂药物开发提供了潜在新策略。(3)深度绘制了多种疾病组织中的新型蛋白翻译后修饰图谱,揭示了不同疾病组织中蛋白翻译后修饰参与转录和代谢调控的新机制,拓展了新型蛋白翻译后修饰的功能。共发表SCI论文61篇,获得美国授权专利5项。其中以第一作者或通讯作者在Cell、Chem Rev、Cell Metab、Mol Cell、Cell Res、Sci Adv、Nat Comms、J Am Chem Soc、J Med Chem等杂志上发表论文27篇。论文总影响因子663,被引用5900余次,H指数36。


教育经历:

2004.9–2010.7   中国科学院上海药物研究所,博士

2000.9–2004.7   同济大学化学系,学士


工作经历

    2022.12至今

    中科环渤海(烟台)药物高等研究院,党委书记

    2019.1至今

    中国科学院上海药物研究所,研究员 ,课题组长

    2015.9–2019.1

    美国芝加哥大学,研究助理 

    2012.11–2015.8

    美国芝加哥大学,博士后 

    2010.8–2012.10

    美国西北大学,博士后

     
     
     
     
研究方向

基于蛋白质动态修饰通路的新靶点鉴定及创新药物研究


科研项目
科研成果

1.揭示了一种小檗碱衍生物发挥降血脂作用的新靶点并阐释了其独特的作用机制,为降血脂药物开发提供了潜在新策略。

2.系统揭示新型蛋白修饰β-羟基丁酰化(Kbhb)的关键调控因子。鉴定出p300和HDAC1/2分别作为Kbhb的“书写器”和“擦除器”,动态调控蛋白Kbhb水平,进而介导细胞中一系列重要的生物学进程。同时,通过全面分析哺乳动物细胞中的Kbhb底物,发现1397个蛋白上共存在3248个Kbhb位点。该研究探索了调控Kbhb的关键酶,拓展了Kbhb调控的蛋白质底物谱,阐释了Kbhb耦合代谢物与多种细胞进程的新机制、新途径,为进一步揭示Kbhb修饰在各种生理、病理条件下的作用提供了理论依据。

3.发现赖氨酸苯甲酰化修饰并阐释其表观遗传调控机制。在哺乳动物细胞中发现和确证了一种全新蛋白质动态修饰——赖氨酸苯甲酰化,并成功鉴定了22个组蛋白赖氨酸苯甲酰化位点及其调控酶SIRT2。该修饰是目前已知的唯一一个赖氨酸芳香烃酰化修饰,并显示出独特的生物学功能。针对该修饰的定量蛋白质组学和深度测序结果显示它与多种疾病代谢通路和基因活化密切相关。因该修饰水平升高而导致的基因表达上调与慢性肾衰竭等多种肾脏疾病呈显著相关性。这些结果表明该修饰可能是特定病理变化过程中的一种重要表观遗传调控因子,因此该项研究为基于表观遗传靶点的创新药物研究带来新的方向并将产生重要影响。

4.深度鉴定二羟基异丁酰化修饰谱并阐释其调控糖酵解的作用机制。鉴定出调控蛋白二羟基异丁酰化修饰的关键酶(p300, Tip60,HDAC2和HDAC3)及其在哺乳动物细胞中的修饰底物谱。利用定量蛋白质组学技术鉴定了肿瘤细胞中受p300选择性调控的二羟基异丁酰化修饰底物,并揭示了p300通过改变蛋白二羟基异丁酰化修饰水平来进行细胞糖代谢调控的全新机理,从而阐明了该动态修饰调节细胞代谢的机制。


荣誉获奖

    2010年 中国科学院院长优秀奖

    2010年 上海市高等学校优秀毕业生

    2010年 礼来亚洲优秀学位论文一等奖


代表论著

      代表论著(2010年以后)

      1.Wang J#, Zhao J#, Yan C#, Xi C#, Wu C, Zhao J, Li F, Ding Y, Zhang R, Qi S, Li X, Liu C, Hou W, Chen H, Wang Y, Wu D, Chen K, Jiang H, Huang H*, Liu H*. Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial. Cell Metab., 2022, 667.

      2.Huang H#,*, Zhang D #, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y*. The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway. Sci. Adv., 2021, 7, eabe2771.

      3.Koronowski K#,*, Greco C#,*, Huang H, Kim J, Fribourgh J, Crosby P, Mathur L, Ren X, Partch C, Jang C, Qiao F, Zhao Y, Sassone-Corsi P. Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation. Cell Rep., 2021, 36, 109487.

      4.Shi W#, Tang F#, Ao J, Yu Q, Liu J, Tang Y, Jiang B, Ren X, Huang H, Yang W*, Huang W*. Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis. Angew. Chem. Int. Ed., 2020, 59, 19940.

      5.Di Zhang#, Zhanyun Tang#, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut, Jun Ding, Daniel Czyz, Rong Hu, Zhen Ye, Maomao He, Y George Zheng, Howard A Shuman, Lunzhi Dai, Bing Ren, Robert G Roeder, Lev Becker*, Yingming Zhao*. Metabolic regulation of gene expression by histone lactylation. Nature 2019, 574, 575.

      6.He Huang#, Di Zhang, Yi Wang, Mathew Perez-Neut, Zhen Han, Y. George Zheng, Quan Hao, Yingming Zhao*. Lysine benzoylation is a histone mark regulated by SIRT2. Nat. Commun. 2018, 9, 3374.

      7.He Huang#, Shuang Tang#, Ming Ji#, Zhanyun Tang, Miho Shimada, Xiaojing Liu, Shankang Qi, Jason W Locasale, Robert G Roeder, Yingming Zhao*, Xiaoling Li*. EP300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. Mol. Cell 2018, 70, 663-678.

      8.He Huang#, Zhouqing Luo#, Shankang Qi#, Jing Huang#, Peng Xu, Xiuxuan Wang, Li Gao, Fangyi Li, Jian Wang, Wenhui Zhao, Wei Gu, Zhucheng Chen, Lunzhi Dai*, Junbiao Dai*, Yingming Zhao*. Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. Cell Res. 2018, 28, 111-125.

      9.Jing Huang#, Zhouqing Luo#, Wantao Ying#, Qichen Cao, He Huang, Junkai Dong, Qingyu Wu, Yingming Zhao, Xiaohong Qian*, Junbiao Dai*. 2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 8782-8787.

      10.Zuzanna Kaczmarska#, Esther Ortega, Afsaneh Goudarzi, He Huang, Sunjoo Kim, José A Márquez, Yingming Zhao, Saadi Khochbin, Daniel Panne*. Structure of p300 in complex with acyl-CoA variants. Nat. Chem. Biol. 2017, 13, 21-25.

      11.Zhongyu Xie#, Di Zhang#, Dongjun Chung#, Zhanyun Tang, He Huang, Lunzhi Dai, Shankang Qi, Jingya Li, Gozde Colak, Yue Chen, Chunmei Xia, Chao Peng, Haibin Ruan, Matt Kirkey, Danli Wang, Lindy M. Jensen, Oh Kwang Kwon, Sangkyu Lee, Scott D Pletcher, Minjia Tan, David B Lombard, Kevin P White, Hongyu Zhao, Jia Li, Robert G Roeder, Xiaoyong Yang*, Yingming Zhao*. Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation. Mol. Cell 2016, 62, 194-206.

      12.Yuanyuan Li#, Benjamin R Sabari#, Tatyana Panchenko#, Hong Wen, Dan Zhao, Haipeng Guan, Liling Wan, He Huang, Zhanyun Tang, Yingming Zhao, Robert G Roeder, Xiaobing Shi, C. David Allis*, Haitao Li*. Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain. Mol. Cell 2016, 62, 181-193.

      13.Afsaneh Goudarzi#, Di Zhang#, He Huang, Sophie Barral, Oh Kwang Kwon, Shankang Qi, Zhanyun Tang, Thierry Buchou, Anne-Laure Vitte, Tieming He, Zhongyi Cheng, Emilie Montellier, Jonathan Gaucher, Sandrine Curtet, Alexandra Debernardi, Guillaume Charbonnier, Denis Puthier, Carlo Petosa, Daniel Panne, Sophie Rousseaux, Robert G Roeder, Yingming Zhao*, Saadi Khochbin*. Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters. Mol. Cell 2016, 62, 169-180.

      14.Inmaculada Martínez-Reyes#, Lauren P Diebold, Hyewon Kong, Michael Schieber, He Huang, Christopher T Hensley, Manan M Mehta, Tianyuan Wang, Janine H Santos, Richard Woychik, Eric Dufour, Johannes N Spelbrink, Samuel E Weinberg, Yingming Zhao, Ralph J De Berardinis, Navdeep S Chandel*. TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions. Mol. Cell 2016, 61, 199-209.

      15.Benjamin R Sabari#, Zhanyun Tang, He Huang, Vladimir Yong-Gonzalez, Henrik Molina, Ha Eun Kong, Lunzhi Dai, Miho Shimada, Justin R Cross, Yingming Zhao, Robert G. Roeder, C. David Allis*. Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation. Mol. Cell 2015, 58, 203-215.

      16.He Huang#, Shu Lin, Benjamin A Garcia, Yingming Zhao*. Quantitative proteomic analysis of histone modifications. Chem. Rev. 2015, 115, 2376-2418.

      17.Jeffrey K Holden#, Soosung Kang, Scott A Hollingsworth, Huiying Li, Nathan Lim, Steven Chen, He Huang, Fengtian Xue, Wei Tang, Richard B Silverman, Thomas L. Poulos*. Structure-based design of bacterial nitric oxide synthase inhibitors. J. Med. Chem. 2015, 58, 994-1004.

      18.He Huang#, Benjamin R Sabari, Benjamin A Garcia, C David Allis, Yingming Zhao*. SnapShot: histone modifications. Cell 2014, 159, 458-458.

      19.Minjia Tan#, Chao Peng#, Kristin A Anderson#, Peter Chhoy, Zhongyu Xie, Lunzhi Dai, Jeongsoon Park, Yue Chen, He Huang, Yi Zhang, Jennifer Ro, Gregory R. Wagner, Michelle F. Green, Andreas S. Madsen, Jessica Schmiesing, Brett S. Peterson, Guofeng Xu, Olga R. Ilkayeva, Michael J. Muehlbauer, Thomas Braulke, Chris Mühlhausen, Donald S. Backos, Christian A. Olsen, Peter J. McGuire, Scott D. Pletcher, David B. Lombard, Matthew D. Hirschey*, Yingming Zhao*. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 2014, 19, 605-617.

      20.He Huang#, Huiying Li, Sun Yang, Georges Chreifi, Pavel Marta?sek, Linda J Roman, Frank L Meyskens, Thomas L Poulos*, Richard B Silverman*. Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma. J. Med. Chem. 2014, 57, 686-700.

      21.He Huang#, Huiying Li, Pavel Martásek, Linda J Roman, Thomas L Poulos*, Richard B Silverman*. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase. J. Med. Chem. 2013, 56, 3024-3032.

      22.He Huang#, Haitao Ji, Huiying Li, Qing Jing, Kristin Jansen Labby, Pavel Martásek, Linda J Roman, Thomas L Poulos*, Richard B Silverman*. Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. J. Am. Chem. Soc. 2012, 134, 11559-11572.

      23.Qian Ba#, Miao Hao#, He Huang#, Junmei Hou, Shichao Ge, Zhuzhen Zhang, Jun Yin, Ruiai Chu, Hualiang Jiang, Fudi Wang, Kaixian Chen, Hong Liu*, Hui Wang*. Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies. Clin. Cancer Res. 2011, 17, 7625-7633.

      24.He Huang#, Qin Chen#, Xin Ku, Linghua Meng*, Liping Lin, Xiang Wang, Caihua Zhu, Yi Wang, Zhi Chen, Ming Li, Hualiang Jiang, Kaixian Chen, Jian Ding, Hong Liu*. A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity. J. Med. Chem. 2010, 53, 3048-3064.

社会任职

黄河

姓 名 黄河 性 别 职 称 研究员
学 历 博士 电 话 传 真
电子邮件 hhuang@simm.ac.cn 个人主页 主页链接 专家类别
职 务 党委书记
通讯地址 烟台市牟平区滨海东路198号
个人简介

    黄河,研究员,博士生导师,课题组长。主要从事基于蛋白质组学的化学生物学研究,包括蛋白质动态修饰通路的发现与调控机制阐释,以及基于蛋白质动态修饰的新靶标发现和药物研发。代表性研究成果:(1)系统地鉴定了赖氨酸?-羟基丁酰化修饰的调控酶,绘制了哺乳动物细胞的?-羟基丁酰化修饰图谱,阐释了该修饰耦合代谢物与多种细胞进程的新机制、新途径;(2)阐明了一种小檗碱衍生物发挥降血脂作用的新靶点及其独特新机制,为降血脂药物开发提供了潜在新策略。(3)深度绘制了多种疾病组织中的新型蛋白翻译后修饰图谱,揭示了不同疾病组织中蛋白翻译后修饰参与转录和代谢调控的新机制,拓展了新型蛋白翻译后修饰的功能。共发表SCI论文61篇,获得美国授权专利5项。其中以第一作者或通讯作者在Cell、Chem Rev、Cell Metab、Mol Cell、Cell Res、Sci Adv、Nat Comms、J Am Chem Soc、J Med Chem等杂志上发表论文27篇。论文总影响因子663,被引用5900余次,H指数36。


    教育经历:

    2004.9–2010.7   中国科学院上海药物研究所,博士

    2000.9–2004.7   同济大学化学系,学士


工作经历

    2022.12至今

    中科环渤海(烟台)药物高等研究院,党委书记

    2019.1至今

    中国科学院上海药物研究所,研究员 ,课题组长

    2015.9–2019.1

    美国芝加哥大学,研究助理 

    2012.11–2015.8

    美国芝加哥大学,博士后 

    2010.8–2012.10

    美国西北大学,博士后

     
     
     
     
研究方向

    基于蛋白质动态修饰通路的新靶点鉴定及创新药物研究


科研项目
科研成果

    1.揭示了一种小檗碱衍生物发挥降血脂作用的新靶点并阐释了其独特的作用机制,为降血脂药物开发提供了潜在新策略。

    2.系统揭示新型蛋白修饰β-羟基丁酰化(Kbhb)的关键调控因子。鉴定出p300和HDAC1/2分别作为Kbhb的“书写器”和“擦除器”,动态调控蛋白Kbhb水平,进而介导细胞中一系列重要的生物学进程。同时,通过全面分析哺乳动物细胞中的Kbhb底物,发现1397个蛋白上共存在3248个Kbhb位点。该研究探索了调控Kbhb的关键酶,拓展了Kbhb调控的蛋白质底物谱,阐释了Kbhb耦合代谢物与多种细胞进程的新机制、新途径,为进一步揭示Kbhb修饰在各种生理、病理条件下的作用提供了理论依据。

    3.发现赖氨酸苯甲酰化修饰并阐释其表观遗传调控机制。在哺乳动物细胞中发现和确证了一种全新蛋白质动态修饰——赖氨酸苯甲酰化,并成功鉴定了22个组蛋白赖氨酸苯甲酰化位点及其调控酶SIRT2。该修饰是目前已知的唯一一个赖氨酸芳香烃酰化修饰,并显示出独特的生物学功能。针对该修饰的定量蛋白质组学和深度测序结果显示它与多种疾病代谢通路和基因活化密切相关。因该修饰水平升高而导致的基因表达上调与慢性肾衰竭等多种肾脏疾病呈显著相关性。这些结果表明该修饰可能是特定病理变化过程中的一种重要表观遗传调控因子,因此该项研究为基于表观遗传靶点的创新药物研究带来新的方向并将产生重要影响。

    4.深度鉴定二羟基异丁酰化修饰谱并阐释其调控糖酵解的作用机制。鉴定出调控蛋白二羟基异丁酰化修饰的关键酶(p300, Tip60,HDAC2和HDAC3)及其在哺乳动物细胞中的修饰底物谱。利用定量蛋白质组学技术鉴定了肿瘤细胞中受p300选择性调控的二羟基异丁酰化修饰底物,并揭示了p300通过改变蛋白二羟基异丁酰化修饰水平来进行细胞糖代谢调控的全新机理,从而阐明了该动态修饰调节细胞代谢的机制。


荣誉获奖

    2010年 中国科学院院长优秀奖

    2010年 上海市高等学校优秀毕业生

    2010年 礼来亚洲优秀学位论文一等奖


代表论著

      代表论著(2010年以后)

      1.Wang J#, Zhao J#, Yan C#, Xi C#, Wu C, Zhao J, Li F, Ding Y, Zhang R, Qi S, Li X, Liu C, Hou W, Chen H, Wang Y, Wu D, Chen K, Jiang H, Huang H*, Liu H*. Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial. Cell Metab., 2022, 667.

      2.Huang H#,*, Zhang D #, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y*. The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway. Sci. Adv., 2021, 7, eabe2771.

      3.Koronowski K#,*, Greco C#,*, Huang H, Kim J, Fribourgh J, Crosby P, Mathur L, Ren X, Partch C, Jang C, Qiao F, Zhao Y, Sassone-Corsi P. Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation. Cell Rep., 2021, 36, 109487.

      4.Shi W#, Tang F#, Ao J, Yu Q, Liu J, Tang Y, Jiang B, Ren X, Huang H, Yang W*, Huang W*. Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis. Angew. Chem. Int. Ed., 2020, 59, 19940.

      5.Di Zhang#, Zhanyun Tang#, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut, Jun Ding, Daniel Czyz, Rong Hu, Zhen Ye, Maomao He, Y George Zheng, Howard A Shuman, Lunzhi Dai, Bing Ren, Robert G Roeder, Lev Becker*, Yingming Zhao*. Metabolic regulation of gene expression by histone lactylation. Nature 2019, 574, 575.

      6.He Huang#, Di Zhang, Yi Wang, Mathew Perez-Neut, Zhen Han, Y. George Zheng, Quan Hao, Yingming Zhao*. Lysine benzoylation is a histone mark regulated by SIRT2. Nat. Commun. 2018, 9, 3374.

      7.He Huang#, Shuang Tang#, Ming Ji#, Zhanyun Tang, Miho Shimada, Xiaojing Liu, Shankang Qi, Jason W Locasale, Robert G Roeder, Yingming Zhao*, Xiaoling Li*. EP300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. Mol. Cell 2018, 70, 663-678.

      8.He Huang#, Zhouqing Luo#, Shankang Qi#, Jing Huang#, Peng Xu, Xiuxuan Wang, Li Gao, Fangyi Li, Jian Wang, Wenhui Zhao, Wei Gu, Zhucheng Chen, Lunzhi Dai*, Junbiao Dai*, Yingming Zhao*. Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. Cell Res. 2018, 28, 111-125.

      9.Jing Huang#, Zhouqing Luo#, Wantao Ying#, Qichen Cao, He Huang, Junkai Dong, Qingyu Wu, Yingming Zhao, Xiaohong Qian*, Junbiao Dai*. 2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 8782-8787.

      10.Zuzanna Kaczmarska#, Esther Ortega, Afsaneh Goudarzi, He Huang, Sunjoo Kim, José A Márquez, Yingming Zhao, Saadi Khochbin, Daniel Panne*. Structure of p300 in complex with acyl-CoA variants. Nat. Chem. Biol. 2017, 13, 21-25.

      11.Zhongyu Xie#, Di Zhang#, Dongjun Chung#, Zhanyun Tang, He Huang, Lunzhi Dai, Shankang Qi, Jingya Li, Gozde Colak, Yue Chen, Chunmei Xia, Chao Peng, Haibin Ruan, Matt Kirkey, Danli Wang, Lindy M. Jensen, Oh Kwang Kwon, Sangkyu Lee, Scott D Pletcher, Minjia Tan, David B Lombard, Kevin P White, Hongyu Zhao, Jia Li, Robert G Roeder, Xiaoyong Yang*, Yingming Zhao*. Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation. Mol. Cell 2016, 62, 194-206.

      12.Yuanyuan Li#, Benjamin R Sabari#, Tatyana Panchenko#, Hong Wen, Dan Zhao, Haipeng Guan, Liling Wan, He Huang, Zhanyun Tang, Yingming Zhao, Robert G Roeder, Xiaobing Shi, C. David Allis*, Haitao Li*. Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain. Mol. Cell 2016, 62, 181-193.

      13.Afsaneh Goudarzi#, Di Zhang#, He Huang, Sophie Barral, Oh Kwang Kwon, Shankang Qi, Zhanyun Tang, Thierry Buchou, Anne-Laure Vitte, Tieming He, Zhongyi Cheng, Emilie Montellier, Jonathan Gaucher, Sandrine Curtet, Alexandra Debernardi, Guillaume Charbonnier, Denis Puthier, Carlo Petosa, Daniel Panne, Sophie Rousseaux, Robert G Roeder, Yingming Zhao*, Saadi Khochbin*. Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters. Mol. Cell 2016, 62, 169-180.

      14.Inmaculada Martínez-Reyes#, Lauren P Diebold, Hyewon Kong, Michael Schieber, He Huang, Christopher T Hensley, Manan M Mehta, Tianyuan Wang, Janine H Santos, Richard Woychik, Eric Dufour, Johannes N Spelbrink, Samuel E Weinberg, Yingming Zhao, Ralph J De Berardinis, Navdeep S Chandel*. TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions. Mol. Cell 2016, 61, 199-209.

      15.Benjamin R Sabari#, Zhanyun Tang, He Huang, Vladimir Yong-Gonzalez, Henrik Molina, Ha Eun Kong, Lunzhi Dai, Miho Shimada, Justin R Cross, Yingming Zhao, Robert G. Roeder, C. David Allis*. Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation. Mol. Cell 2015, 58, 203-215.

      16.He Huang#, Shu Lin, Benjamin A Garcia, Yingming Zhao*. Quantitative proteomic analysis of histone modifications. Chem. Rev. 2015, 115, 2376-2418.

      17.Jeffrey K Holden#, Soosung Kang, Scott A Hollingsworth, Huiying Li, Nathan Lim, Steven Chen, He Huang, Fengtian Xue, Wei Tang, Richard B Silverman, Thomas L. Poulos*. Structure-based design of bacterial nitric oxide synthase inhibitors. J. Med. Chem. 2015, 58, 994-1004.

      18.He Huang#, Benjamin R Sabari, Benjamin A Garcia, C David Allis, Yingming Zhao*. SnapShot: histone modifications. Cell 2014, 159, 458-458.

      19.Minjia Tan#, Chao Peng#, Kristin A Anderson#, Peter Chhoy, Zhongyu Xie, Lunzhi Dai, Jeongsoon Park, Yue Chen, He Huang, Yi Zhang, Jennifer Ro, Gregory R. Wagner, Michelle F. Green, Andreas S. Madsen, Jessica Schmiesing, Brett S. Peterson, Guofeng Xu, Olga R. Ilkayeva, Michael J. Muehlbauer, Thomas Braulke, Chris Mühlhausen, Donald S. Backos, Christian A. Olsen, Peter J. McGuire, Scott D. Pletcher, David B. Lombard, Matthew D. Hirschey*, Yingming Zhao*. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 2014, 19, 605-617.

      20.He Huang#, Huiying Li, Sun Yang, Georges Chreifi, Pavel Marta?sek, Linda J Roman, Frank L Meyskens, Thomas L Poulos*, Richard B Silverman*. Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma. J. Med. Chem. 2014, 57, 686-700.

      21.He Huang#, Huiying Li, Pavel Martásek, Linda J Roman, Thomas L Poulos*, Richard B Silverman*. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase. J. Med. Chem. 2013, 56, 3024-3032.

      22.He Huang#, Haitao Ji, Huiying Li, Qing Jing, Kristin Jansen Labby, Pavel Martásek, Linda J Roman, Thomas L Poulos*, Richard B Silverman*. Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. J. Am. Chem. Soc. 2012, 134, 11559-11572.

      23.Qian Ba#, Miao Hao#, He Huang#, Junmei Hou, Shichao Ge, Zhuzhen Zhang, Jun Yin, Ruiai Chu, Hualiang Jiang, Fudi Wang, Kaixian Chen, Hong Liu*, Hui Wang*. Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies. Clin. Cancer Res. 2011, 17, 7625-7633.

      24.He Huang#, Qin Chen#, Xin Ku, Linghua Meng*, Liping Lin, Xiang Wang, Caihua Zhu, Yi Wang, Zhi Chen, Ming Li, Hualiang Jiang, Kaixian Chen, Jian Ding, Hong Liu*. A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity. J. Med. Chem. 2010, 53, 3048-3064.

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