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药物化学

于金海

姓 名 于金海 性 别 职 称 副研究员、硕导
学 历 博士 电 话 0535-6821613 传 真
电子邮件 jhyu@baridd.ac.cn 个人主页 主页链接 专家类别
职 务 副研究员、硕导
通讯地址 烟台市牟平区滨海东路198号
个人简介
工作经历
     
     
     
     
研究方向

1.基于药用植物生物活性分子的发现、结构修饰和药理作用机制研究;

2.基于植物内生真菌生物活性分子的发现、生物合成、结构修饰和药理作用机制研究


科研项目

    1. 2019.01-2021.12:国家自然科学基金(青年科学基金项目),中药枸骨中11β-HSD1选择性抑制剂18,19-secoursane皂苷的定向发现、结构优化及构效关系研究,项目负责人。

    2. 2018.03-2020.12:山东省自然科学基金(博士基金),南欧大戟中Aurora A激酶抑制剂的发现和结构修饰研究,项目负责人。


科研成果
荣誉获奖
    代表论著

      1. J. H. Yu, B. Zhou, P. Q. Wu, Q. F. Liu and J. M. Yue, Cipacinoids E–O: Eleven limonoids represent two different scaffolds from Cipadessa cinerascens, Tetrahedron, 2022, 103, 132566.

      2. J. H. Yu, Z. P. Yu, R. J. Capon and H. Zhang, Natural Enantiomers: Occurrence, Biogenesis and Biological Properties, Molecules, 2022, 27, 1279.

      3. J. H. Yu, S. J. Yu, K. L. Liu, C. Wang, C. Liu, J. Y. Sun and H. Zhang, Cytotoxic ergostane-type steroids from Ganoderma lingzhi, Steroids, 2021, 165, 108767.

      4. S. J. Yu, Z. P. Yu, S. J. Yu, Z. P. Yu, Y. Y. Wang, J. Bao, T. Yuan, J. H. Yu,* and H. Zhang,* Structural characterization and biological evaluation of chemical constituents from Ilex cornuta, J Asian Nat Prod Res, 2020, 22, 316-328.

      5. J. H. Yu, H. Zhang, B. Zhou, F. M. Zimbres, S. Dalal, Q. F. Liu, M. B. Cassera and J. M. Yue, Limonoids from Cipadessa baccifera, J Nat Prod, 2020, 83, 1751-1765.

      6. H. J. Zhai,1 J. H. Yu,1 Q. Zhang, H. S. Liu, J. S. Zhang, X. Q. Song, Y. Zhang and H. Zhang, Cytotoxic and antibacterial triterpenoids from the roots of Morinda officinalis var. officinalis, Fitoterapia, 2019, 133, 56-61.

      7. Z. P. Yu, J. S. Zhang, Q. Zhang, S. J. Yu, Y. Zhang, J. H. Yu* and H. Zhang,* Bioactive sesquiterpenoids and sesquiterpenoid glucosides from the flowers of Inula japonica, Fitoterapia, 2019, 138, 104292.

      8. Z. P. Yu, Y. Y. Wang, S. J. Yu, J. Bao, J. H. Yu*and H. Zhang,* Absolute structure assignment of an iridoid-monoterpenoid indole alkaloid hybrid from Dipsacus asper, Fitoterapia, 2019, 135, 99-106.

      9. S. J. Yu, Z. P. Yu, Y. Y. Wang, J. Bao, T. Yuan, J. H. Yu* and H. Zhang,* Structural characterization and biological evaluation of chemical constituents from Ilex cornuta, J Asian Nat Prod Res, 2019, 316-328.

      10. J. H. Yu, H. J. Zhai, Z. P. Yu, Q. Q. Zhang, Y. X. Ge, Y. Y. Zhang, C. S. Jiang and H. Zhang, Methyl 2-naphthoates from a traditional Chinese herb Morinda officinalis var. officinalis, Tetrahedron, 2019, 75, 3793-3801.

      11. J. H. Yu, Z. P. Yu, D. X. Wu, X. Yan, Y. Y. Wang, H. Zhang, Z. P. Yu and X. Yan, Cuceolatins A-D: New Bioactive Diterpenoids from the Leaves of Cunninghamia lanceolata, Chem Biodivers, 2019, 16, e1900317.

      12. J. H. Yu, D. X. Wu, Z. P. Yu, Y. P. Li, Y. Y. Wang, S. J. Yu and H. Zhang, New e:b-Friedo-Hopane Type Triterpenoids from Euphorbia peplus with Simiarendiol Possessing Significant Cytostatic Activity against HeLa Cells by Induction of Apoptosis and S/G2 Cell Cycle Arrest, Molecules, 2019, 24, 3106.

      13. J. H. Yu, Z. P. Yu, Y. Y. Wang, J. Bao, K. K. Zhu, T. Yuan and H. Zhang, Triterpenoids and triterpenoid saponins from Dipsacus asper and their cytotoxic and antibacterial activities, Phytochemistry, 2019, 162, 241-249.

      14. J. Sun,1 J. H. Yu,1 J. S. Zhang, X. Q. Song, J. Bao and H. Zhang, Chromane Enantiomers from the Flower Buds of Tussilago farfara L. and Assignments of Their Absolute Configurations, Chem Biodivers, 2019, 16, e1800581.

      15. S. Li,1 J. H. Yu,1 Y. Y. Fan,1 Q. F. Liu, Z. C. Li, Z. X. Xie, Y. Li and J. M. Yue, Structural Elucidation and Total Synthesis of Three 9-Norlignans from Curculigo capitulata, J Org Chem, 2019, 84, 5195-5202.

      16. C. S. Jiang, Y. Y. Wang, J. T. Song and J. H. Yu, Acylphloroglucinols as kinase inhibitors from Sargassum nigrifoloides, J Asian Nat Prod Res, 2019, 21, 619-626.

      17. J. H. Yu, B. Zhou, S. Dalal, Q. Liu, M. B. Cassera and J. Yue, Cipaferoids A-C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera, Chin J Chem, 2018, 36, 124-128.

      18. J. H. Yu, Q. F. Liu, L. Sheng, G. C. Wang, J. Li and J. M. Yue, Cipacinoids A–D, Four Limonoids with Spirocyclic Skeletons from Cipadessa cinerascens, Org Lett, 2016, 18, 444-447.

       


    社会任职

    于金海

    姓 名 于金海 性 别 职 称 副研究员、硕导
    学 历 博士 电 话 0535-6821613 传 真
    电子邮件 jhyu@baridd.ac.cn 个人主页 主页链接 专家类别
    职 务 副研究员、硕导
    通讯地址 烟台市牟平区滨海东路198号