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药物化学

张传瑞

姓 名 张传瑞 性 别 职 称 研究员、博导
学 历 博士 电 话 18302335377 传 真
电子邮件 crzhang@baridd.ac.cn 个人主页 主页链接 专家类别
职 务 课题组长、博导
通讯地址 烟台市牟平区滨海东路198号
个人简介
工作经历
     
     
     
     
研究方向

1. 药用植物或真菌中新颖结构和活性化合物的发现、先导化合物的构效研究和结构优化以及新药研发

2. 药食两用植物或功能性食品中活性物质的发现、作用机制研究以及保健品开发

3. 中药药效物质基础和药理作用机制以及中药现代化


科研项目

      1. 国家自然科学基金面上项目,厚壳桂属特征性成分及其抑制4E-BP1磷酸化的抗肿瘤作用研究,主持,2022.01-2025.12

      2. 国家自然科学基金重点项目,天然产物对雌激素合成和代谢调控机制的研究,课题主持人(项目负责人:中国科学院成都生物研究所张国林研究员),结题

      3. 国家自然科学基金青年科学基金,两种桃花心木属植物中生物活性成分的研究,主持,结题

      4. 重庆市自然科学基金面上项目,中药小花八角中抗乙肝病毒活性先导化合物的发现及其药理作用机制研究,主持,结题 



科研成果

已在国际知名期刊Org. Lett.、J. Nat. Prod.、Food Chem.、J. Agric. Food Chem.等以第一或通讯作者发表论文约40篇

荣誉获奖

      2010年 上海市自然科学一等奖(岳建民、杨升平、丁健、张传瑞、尹胜)

      2009年 中国药学会科学技术奖二等奖(岳建民、杨升平、丁健、张传瑞、尹胜)

      2009年 上海药物研究所优秀青年科技工作者

      2008年 上海药学科技奖一等奖(岳建民、杨升平、丁健、张传瑞、尹胜)

      2008年 中国科学院朱李月华优秀博士生奖学金 



代表论著

      1.Yan Wen#, Li Rao#, Fan Xu, Yang Li, Yong-Xin Luo, Xu Gong, Ri-Hui Wu, Chuan-Rui Zhang*, Li-She Gan*. Six pairs of phenylpropanoid enantiomers from Cinnamomum mollifolium. Phytochemistry 2022, 203, 113348.

      2.Li Rao#, Yu Su#, Qian He#, Jia Ye, Yu Liu, Yue Fan, Feng Hu, Zhen Zhou, Li-She Gan, Yonghui Zhang*, Chuan-Rui Zhang*. Geranylated or prenylated flavonoids from Cajanus volubilis. Chinese Journal of Natural Medicines 2022, 20(0): 1−6. doi: 10.1016/S1875-5364(22)60215-2.

      3.Qian He#, Simin Li#, Yue Fan, Yu Liu, Yu Su, Zhen Zhou, Yi-Nan Zhang, Guo-Li Li*, Li Rao*, Chuan-Rui Zhang*. Complex flavanones from Cryptocarya metcalfiana and structural revision of oboflavanone A. Journal of Natural Products 2022, 85, 1617−1625.

      4.Yu Liu, Yun-Xia You, Li Rao, Qian He, Yu Su, Yue Fan, Yizhou Li, You-Kai Xu, Chuan-Rui Zhang*. Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity. Chinese Journal of Natural Medicines 2022, 20, 139−147.

      5.Qian He, Yue Fan, Yu Liu, Li Rao, Yun-Xia You, Yu Su, Zhen Zhou, You-Kai Xu, Chuan-Rui Zhang*. Cryptoyunnanones A‒H, complex flavanones from Cryptocarya yunnanensis. Journal of Natural Products 2021, 84, 2209−2216.

      6.Li Rao, Yao Li, Qian He, Yu Liu, Yu Su, Yun-Xia You, Yue Fan, Bin Lin, Yi-Nan Zhang, Chuan-Rui Zhang*. Iridoid constituents of Viburnum brachybotryum. Journal of Natural Products 2021, 84, 1915−1923.

      7.Li Rao, Yun-Xia You, Yu Su, Yue Fan, Yu Liu, Qian He, Yi Chen, Jie Meng, Lin Hu, Yizhou Li, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*. Lignans and neolignans with antioxidant and human cancer cell proliferation inhibitory activities from Cinnamomum bejolghota confirm its functional food property. Journal of Agricultural and Food Chemistry 2020, 68, 8825−8835.

      8.Hong-Yan Xu#, Ji-Hua Ren#, Yu Su#, Fang Ren, Yu-Jiao Zhou, Hui Jiang, Sheng-Tao Cheng, Chuan-Rui Zhang*, Juan Chen*. Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim. Journal of Ethnopharmacology 2020, 257, 112787. 

      9.Wei Li, Li Rao, Yu Liu, Qian He, Yue Fan, Yun-Xia You, Yu Su, Feng Hu, You-Kai Xu, Bin Lin, Sheng Yin, Chuan-Rui Zhang*. (±)-Meliviticines A and B: rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity. Bioorganic Chemistry 2019, 90, 103099.

      10.Chuan-Rui Zhang, Wajid Khan, Jehan Bakht, Muraleedharan G. Nair*. New antiinflammatory sucrose esters in the natural sticky coating of tomatillo (Physalis philadelphica), an important culinary fruit. Food Chemistry 2016, 196, 726-732. 

      11.Chuan-Rui Zhang, Amila A. Dissanayake, Kudret Kevseroğlu, Muraleedharan G. Nair*. Evaluation of coriander spice as a functional food by using in vitro bioassays. Food Chemistry 2015, 167, 24-29. 

      12.Chuan-Rui Zhang, Amila A. Dissanayake, Muraleedharan G. Nair*. Functional food property of honey locust (Gleditsia triacanthos) flowers. Journal of Functional Foods 2015, 18, 266-274. 

      13.Chuan-Rui Zhang, Saleh A. Aldosari, Polana S. P. V. Vidyasagar, Karun M. Nair, Muraleedharan G. Nair*. Antioxidant and anti-inflammatory assays confirm bioactive compounds in ajwa date fruit. Journal of Agricultural and Food Chemistry 2013, 61, 5834-5840.

      14.Chuan-Rui Zhang#, Cheng-Qi Fan#, Shi-Hui Dong, Hong-Bing Liu, Wen-Bin Zhou, Yan Wu, Jian-Min Yue*. Angustimine and angustifolimine, two new alkaloids from Daphniphyllum angustifolium. Organic Letters 2011, 13, 2440-2443. (#同等贡献)

      15.Chuan-Rui Zhang, Hong-Bing Liu, Shi-Hui Dong, Jian-Yong Zhu, Yan Wu, Jian-Min Yue*. Calycinumines A and B, two novel alkaloids from Daphniphyllum calycinum. Organic Letters 2009, 11, 4692-4695. 

      16.Chuan-Rui Zhang, Hong-Bing Liu, Shi-Hui Dong, Jian-Yong Zhu, Yan Wu, Jian-Min Yue*. Alkaloids from the leaves of Daphniphyllum subverticillatum. Journal of Natural Products 2009, 72, 1669-1672. 

      17.Chuan-Rui Zhang, Sheng-Ping Yang, Yan Wu, Jian-Min Yue*. Alkaloids from the twigs of Daphniphyllum calycinum. Journal of Natural Products 2008, 71, 1663-1668. 

      18.Chuan-Rui Zhang, Cheng-Qi Fan, Li Zhang, Sheng-Ping Yang, Yan Wu, Yang Lu, Jian-Min Yue*. Chuktabrins A and B, two novel limonoids from the twigs and leaves of Chukrasia tabularis. Organic Letters 2008, 10, 3183-3186.

      19.Chuan-Rui Zhang, Sheng-Ping Yang, Shang-Gao Liao, Cheng-Qi Fan, Yan Wu, Jian-Min Yue*. Chuktabularins A-D, four new limonoids with unprecedented carbon skeletons from the stem bark of Chukrasia tabularis. Organic Letters 2007, 9, 3383-3386. 

      20.Chuan-Rui Zhang, Sheng-Ping Yang, Qiao Zhu, Shang-Gao Liao, Yan Wu, Jian-Min Yue. Nortriterpenoids from Chukrasia tabularis var. velutina. Journal of Natural Products 2007, 70, 1616-1619.



社会任职

张传瑞

姓 名 张传瑞 性 别 职 称 研究员、博导
学 历 博士 电 话 18302335377 传 真
电子邮件 crzhang@baridd.ac.cn 个人主页 主页链接 专家类别
职 务 课题组长、博导
通讯地址 烟台市牟平区滨海东路198号