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药物化学

韩海浩

姓 名 韩海浩 性 别 职 称 副研究员、硕导
学 历 博士 电 话 传 真
电子邮件 hanhaihao@simm.ac.cn 个人主页 主页链接 专家类别
职 务 青年课题组长、硕导
通讯地址 烟台市牟平区滨海东路198号
个人简介

韩海浩,中国科学院上海药物研究所/中科环渤海(烟台)药物高等研究院/烟台新药创制山东省实验室副研究员,青年课题组长,中国化学会会员。2020年6月于华东理工大学获工学博士学位,2020年7月-2022年6月于华东理工大学化学博士后科研流动站从事博士后研究工作。迄今已发表SCI论文40余篇,其中以共同通讯/第一(含共一)作者在J. Am. Chem. Soc.(3篇), Chem. Soc. Rev.(2篇), Chem. Sci.(5篇), Theranostics(1篇), Sci. Bull.(1篇), Coord. Chem. Rev.(1篇), Anal. Chem.(1篇)等国内外知名期刊发表论文24篇,总引用> 2400,H因子19。曾获山东省优秀毕业生、博士研究生国家奖学金、高水平期刊论文奖、第五届世界诊疗大会旅行奖等奖励。作为项目负责人,主持了国家自然科学基金面上项目、国家自然科学基金青年科学基金项目、中国博士后科学基金面上资助项目、山东省烟台市科技创新发展计划基础研究项目,以及华东理工大学首届“张江树”优博培育计划等项目,并作为研究骨干参与1项国家自然科学基金重大研究计划重点支持项目与1项国家自然科学基金重大研究计划集成项目。近期,担任《iRADIOLOGY》创刊(Wiley出版)青年编委,并受邀担任《Frontier in Chemistry》国际期刊评审编辑(Review Editor),同时担任英国皇家化学会国际期刊同行评议员与上海市科技专家库专家成员等。

工作经历

    2022.07-至今

    中国科学院上海药物研究所/中科环渤海(烟台)药物高等研究院/烟台新药创制山东省实验室,青年课题组长、副研究员

    2020.07-2022.06 

    华东理工大学,化学博士后科研流动站,博士后

     
     
     
     
研究方向

1.恶性肿瘤、代谢性疾病和神经系统疾病的靶向纳米药物递释系统开发;

2.恶性肿瘤、代谢性疾病和神经系统疾病的可视化荧光化学诊疗探针创制;

3.人类重大疾病的糖靶向药研发与临床转化。

科研项目

    2024.01-2027.12

    1.国家自然科学基金面上项目,在研、项目负责人。

    2022.01-2024.12

    2.国家自然科学基金青年科学基金项目,在研、项目负责人。

    2020.07–2022.06

    3.中国博士后科学基金面上资助项目,已结题、项目负责人。

    2023.01-2025.12

    4.山东省烟台市科技创新发展计划基础研究项目,在研、项目负责人。

    2019.01-2022.12

    5.国家自然科学基金重大研究计划重点支持项目,已结题、参与。

    2023.01-2025.12

    6.国家自然科学基金重大研究计划集成项目,在研、参与。


科研成果

迄今已发表SCI论文40余篇,其中以共同通讯或第一(含共一)作者在J. Am. Chem. Soc.(3篇), Chem. Soc. Rev.(2篇), Chem. Sci.(5篇), Theranostics(1篇), Sci. Bull.(1篇), Coord. Chem. Rev.(1篇), Anal. Chem.(1篇)等国内外知名期刊发表论文24篇,总引用> 2400,H因子19。

荣誉获奖

    1.第五届世界诊疗大会旅行奖  

    2.博士研究生国家奖学金

    3.高水平期刊论文奖

    4.山东省优秀毕业生

代表论著

    1.Hai-Hao Han, Han-Min Wang, Paramesh Jangili, Mingle Li, Luling Wu*, Yi Zang, Adam C Sedgwick*, Jia Li*, Xiao-Peng He*, Tony D James*, Jong Seung Kim*. The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy. Chemical Society Reviews. 2023, 52: (3), 879-920.

    2.Hai-Hao Han, He Tian Jr., Yi Zang, Adam C Sedgwick, Jia Li*, Jonathan L Sessler*, Xiao-Peng He*, Tony D. James*. Small-molecule fluorescence-based probes for interrogating major organ diseases. Chemical Society Reviews. 2021, 50: (17), 9391-9429. 

    3.Hai-Hao Han#, Adam C Sedgwick#, Ying Shang#, Na Li, Tingting Liu, Bo-Han Li, Kunqian Yu, Yi Zang, James T Brewster, Maria L Odyniec, Maria Weber, Steven D Bull, Jia Li*, Jonathan L Sessler*, Tony D James*, Xiao-Peng He*, He Tian. Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes. Chemical Science. 2020, 11, 1107-1113

    4.Hai-Hao Han#, Yu-Jiao Qiu#, Yuan-Yuan Shi#, Wen Wen, Xiao-Peng He*, Li-Wei Dong*, Ye-Xiong Tan*, Yi-Tao Long, He Tian, Hong-Yang Wang*. Glypican-3-targeted precision diagnosis of hepatocellular carcinoma on clinical sections with a supramolecular 2D imaging probe. Theranostics. 2018, 8: (12), 3268. 

    5.Xianzhi Chai#, Hai-Hao Han#, Adam C. Sedgwick#, Na Li, Yi Zang, Tony D. James, Junji Zhang*, Xi-Le Hu, Yang Yu, Yao Li, Yan Wang, Jia Li*, Xiao-Peng He*, He Tian. Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers. Journal of the American Chemical Society. 2020, 142: (42), 18005-18013. 

    6.Youxin Fu#, Hai-Hao Han#, Junji Zhang*, Xiao-Peng He*, Ben L Feringa, He Tian*. Photocontrolled fluorescence “double-check” bioimaging enabled by a glycoprobe–protein hybrid. Journal of the American Chemical Society. 2018, 140: (28), 8671-8674. 

    7.Xianzhi Chai#, Bohan Li#, Chi Chen, Weijian Zhang, Lulu Sun, Hai-Hao Han*, Yafei Zhang, Shasha Sun*, Jianming Yang, Junji Zhang*, Xiao-Peng He*. A Highly Sensitive and Selective Near-Infrared Fluorescent Probe for Imaging Peroxynitrite in Living Cells and Drug-Induced Liver Injury Mice. Analytical Chemistry. 2023, 95: (13), 5747-5753.

    8.Hai-Hao Han, Chang Zheng Wang, Yi Zang, Jia Li*, Tony D James, Xiao-Peng He*. Supramolecular core–glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy. Chemical Communications. 2017, 53: (70), 9793-9796. 

    9.Cherie Cy Wong, Lu-Lu Sun, Meng-Jiao Liu, Eleanor Stride, Jason L Raymond, Hai-Hao Han*, James Kwan*, Adam C Sedgwick*. Fluorescence-based chemical tools for monitoring ultrasound-induced hydroxyl radical production in aqueous solution and in cells. Chemical Communications. 2023, 59: (29), 4328-4331.

    10.Hai-Na Xie#, Yu-Yuan Chen#, Guo-Biao Zhu, Hai-Hao Han*, Xile Hu, Zhi-Qiang Pan, Yi Zang, Donghao Xie*, Xiao-Peng He, Jia Li*, Tony D. James*. Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial. Chemical Communications. 2022, 58 (32), 5029-5032. 

    11.Luling Wu#, Jihong Liu#, Xue Tian#, Robin R. Groleau, Beidou Feng, Yonggang Yang, Adam C. Sedgwick, Hai-Hao Han*, Yang Wang, Han-Min Wang, Fang Huang, Steven D. Bull, Hua Zhang*, Chusen Huang*, Yi Zang, Jia Li, Xiao-Peng He, Ping Li*, Bo Tang, Tony D. James*, Jonathan L. Sessler*. Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5'-triphosphate in Cellular Applications. Journal of the American Chemical Society. 2022, 144: (1), 174-183. 

    12.Adam C Sedgwick#, Hai-Hao Han#, Jordan E Gardiner, Steven D Bull*, Xiao-Peng He*, Tony D James*. The development of a novel AND logic based fluorescence probe for the detection of peroxynitrite and GSH. Chemical Science. 2018, 9: (15), 3672-3676. 

    13.Changzheng Wang#, Hai-Hao Han#, Xinying Tang, Dongming Zhou*, Changfeng Wu, Guorong Chen, Xiao-Peng He*, He Tian. Sialylglycan-assembled supra-dots for ratiometric probing and blocking of human-infecting influenza viruses. ACS Applied Materials & Interfaces. 2017, 9: (30), 25164-25170. 

    14.Wei-Tao Dou#, Hai-Hao Han#, Adam C.Sedgwick, Guo-Biao Zhu, Yi Zang, Xin-Rong Yang*, Juyoung Yoon*, Tony D. James*, Jia Li*, Xiao-Peng He*. Fluorescent probes for the detection of disease-associated biomarkers. Science Bulletin. 2022, 67, 853-878. 

    15.Maria Weber#, Hai-Hao Han#, Bo-Han Li#, Maria L. Odyniec, Charlotte E. F. Jarman, Yi Zang, Steven D. Bull, Amanda B. Mackenzie, Adam C. Sedgwick*, Jia Li*, Xiao-Peng He*, Tony D. James*. Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications. Chemical Science. 2020, 11: (32), 8567-8571. 

    16.Lei Dong#, Min-Yu Zhang#, Hai-Hao Han#, Yi Zang, Guo-Rong Chen, Jia Li*, Xiao-Peng He*, Sébastien Vidal*. A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters. Chemical Science. 2022, 13: (1), 247-256. 

    17.He Tian Jr.#, Adam C. Sedgwick#, Hai-Hao Han#, Sajal Sen, Guo-Rong Chen, Yi Zang, Jonathan L. Sessler*, Tony D. James*, Jia Li*, Xiao-Peng He*. Fluorescent probes for the imaging of lipid droplets in live cells. Coordination Chemistry Reviews. 2021, 427, 213577.

    18.Yueci Wu#, Hai-Hao Han#, Liu He, Li Li, Yi Zang, Jia Li*, Xiao-Peng He*, Yaping Ding*, Weiguo Cao*, Tony D James*. Selective detection of peroxynitrite using an isatin receptor and a naphthalimide fluorophore. Chemical Communications. 2023, 59: (34), 5051-5054.

社会任职

1.中国化学会会员

2.《iRADIOLOGY》创刊(Wiley出版)青年编委

3.《Frontier in Chemistry》期刊评审编辑(Review Editor)

4.英国皇家化学会国际期刊同行评议员

韩海浩

姓 名 韩海浩 性 别 职 称 副研究员、硕导
学 历 博士 电 话 传 真
电子邮件 hanhaihao@simm.ac.cn 个人主页 主页链接 专家类别
职 务 青年课题组长、硕导
通讯地址 烟台市牟平区滨海东路198号
个人简介

    韩海浩,中国科学院上海药物研究所/中科环渤海(烟台)药物高等研究院/烟台新药创制山东省实验室副研究员,青年课题组长,中国化学会会员。2020年6月于华东理工大学获工学博士学位,2020年7月-2022年6月于华东理工大学化学博士后科研流动站从事博士后研究工作。迄今已发表SCI论文40余篇,其中以共同通讯/第一(含共一)作者在J. Am. Chem. Soc.(3篇), Chem. Soc. Rev.(2篇), Chem. Sci.(5篇), Theranostics(1篇), Sci. Bull.(1篇), Coord. Chem. Rev.(1篇), Anal. Chem.(1篇)等国内外知名期刊发表论文24篇,总引用> 2400,H因子19。曾获山东省优秀毕业生、博士研究生国家奖学金、高水平期刊论文奖、第五届世界诊疗大会旅行奖等奖励。作为项目负责人,主持了国家自然科学基金面上项目、国家自然科学基金青年科学基金项目、中国博士后科学基金面上资助项目、山东省烟台市科技创新发展计划基础研究项目,以及华东理工大学首届“张江树”优博培育计划等项目,并作为研究骨干参与1项国家自然科学基金重大研究计划重点支持项目与1项国家自然科学基金重大研究计划集成项目。近期,担任《iRADIOLOGY》创刊(Wiley出版)青年编委,并受邀担任《Frontier in Chemistry》国际期刊评审编辑(Review Editor),同时担任英国皇家化学会国际期刊同行评议员与上海市科技专家库专家成员等。

工作经历

    2022.07-至今

    中国科学院上海药物研究所/中科环渤海(烟台)药物高等研究院/烟台新药创制山东省实验室,青年课题组长、副研究员

    2020.07-2022.06 

    华东理工大学,化学博士后科研流动站,博士后

     
     
     
     
研究方向

    1.恶性肿瘤、代谢性疾病和神经系统疾病的靶向纳米药物递释系统开发;

    2.恶性肿瘤、代谢性疾病和神经系统疾病的可视化荧光化学诊疗探针创制;

    3.人类重大疾病的糖靶向药研发与临床转化。

科研项目

    2024.01-2027.12

    1.国家自然科学基金面上项目,在研、项目负责人。

    2022.01-2024.12

    2.国家自然科学基金青年科学基金项目,在研、项目负责人。

    2020.07–2022.06

    3.中国博士后科学基金面上资助项目,已结题、项目负责人。

    2023.01-2025.12

    4.山东省烟台市科技创新发展计划基础研究项目,在研、项目负责人。

    2019.01-2022.12

    5.国家自然科学基金重大研究计划重点支持项目,已结题、参与。

    2023.01-2025.12

    6.国家自然科学基金重大研究计划集成项目,在研、参与。


科研成果

    迄今已发表SCI论文40余篇,其中以共同通讯或第一(含共一)作者在J. Am. Chem. Soc.(3篇), Chem. Soc. Rev.(2篇), Chem. Sci.(5篇), Theranostics(1篇), Sci. Bull.(1篇), Coord. Chem. Rev.(1篇), Anal. Chem.(1篇)等国内外知名期刊发表论文24篇,总引用> 2400,H因子19。

荣誉获奖

    1.第五届世界诊疗大会旅行奖  

    2.博士研究生国家奖学金

    3.高水平期刊论文奖

    4.山东省优秀毕业生

代表论著

1.Hai-Hao Han, Han-Min Wang, Paramesh Jangili, Mingle Li, Luling Wu*, Yi Zang, Adam C Sedgwick*, Jia Li*, Xiao-Peng He*, Tony D James*, Jong Seung Kim*. The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy. Chemical Society Reviews. 2023, 52: (3), 879-920.

2.Hai-Hao Han, He Tian Jr., Yi Zang, Adam C Sedgwick, Jia Li*, Jonathan L Sessler*, Xiao-Peng He*, Tony D. James*. Small-molecule fluorescence-based probes for interrogating major organ diseases. Chemical Society Reviews. 2021, 50: (17), 9391-9429. 

3.Hai-Hao Han#, Adam C Sedgwick#, Ying Shang#, Na Li, Tingting Liu, Bo-Han Li, Kunqian Yu, Yi Zang, James T Brewster, Maria L Odyniec, Maria Weber, Steven D Bull, Jia Li*, Jonathan L Sessler*, Tony D James*, Xiao-Peng He*, He Tian. Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes. Chemical Science. 2020, 11, 1107-1113

4.Hai-Hao Han#, Yu-Jiao Qiu#, Yuan-Yuan Shi#, Wen Wen, Xiao-Peng He*, Li-Wei Dong*, Ye-Xiong Tan*, Yi-Tao Long, He Tian, Hong-Yang Wang*. Glypican-3-targeted precision diagnosis of hepatocellular carcinoma on clinical sections with a supramolecular 2D imaging probe. Theranostics. 2018, 8: (12), 3268. 

5.Xianzhi Chai#, Hai-Hao Han#, Adam C. Sedgwick#, Na Li, Yi Zang, Tony D. James, Junji Zhang*, Xi-Le Hu, Yang Yu, Yao Li, Yan Wang, Jia Li*, Xiao-Peng He*, He Tian. Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers. Journal of the American Chemical Society. 2020, 142: (42), 18005-18013. 

6.Youxin Fu#, Hai-Hao Han#, Junji Zhang*, Xiao-Peng He*, Ben L Feringa, He Tian*. Photocontrolled fluorescence “double-check” bioimaging enabled by a glycoprobe–protein hybrid. Journal of the American Chemical Society. 2018, 140: (28), 8671-8674. 

7.Xianzhi Chai#, Bohan Li#, Chi Chen, Weijian Zhang, Lulu Sun, Hai-Hao Han*, Yafei Zhang, Shasha Sun*, Jianming Yang, Junji Zhang*, Xiao-Peng He*. A Highly Sensitive and Selective Near-Infrared Fluorescent Probe for Imaging Peroxynitrite in Living Cells and Drug-Induced Liver Injury Mice. Analytical Chemistry. 2023, 95: (13), 5747-5753.

8.Hai-Hao Han, Chang Zheng Wang, Yi Zang, Jia Li*, Tony D James, Xiao-Peng He*. Supramolecular core–glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy. Chemical Communications. 2017, 53: (70), 9793-9796. 

9.Cherie Cy Wong, Lu-Lu Sun, Meng-Jiao Liu, Eleanor Stride, Jason L Raymond, Hai-Hao Han*, James Kwan*, Adam C Sedgwick*. Fluorescence-based chemical tools for monitoring ultrasound-induced hydroxyl radical production in aqueous solution and in cells. Chemical Communications. 2023, 59: (29), 4328-4331.

10.Hai-Na Xie#, Yu-Yuan Chen#, Guo-Biao Zhu, Hai-Hao Han*, Xile Hu, Zhi-Qiang Pan, Yi Zang, Donghao Xie*, Xiao-Peng He, Jia Li*, Tony D. James*. Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial. Chemical Communications. 2022, 58 (32), 5029-5032. 

11.Luling Wu#, Jihong Liu#, Xue Tian#, Robin R. Groleau, Beidou Feng, Yonggang Yang, Adam C. Sedgwick, Hai-Hao Han*, Yang Wang, Han-Min Wang, Fang Huang, Steven D. Bull, Hua Zhang*, Chusen Huang*, Yi Zang, Jia Li, Xiao-Peng He, Ping Li*, Bo Tang, Tony D. James*, Jonathan L. Sessler*. Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5'-triphosphate in Cellular Applications. Journal of the American Chemical Society. 2022, 144: (1), 174-183. 

12.Adam C Sedgwick#, Hai-Hao Han#, Jordan E Gardiner, Steven D Bull*, Xiao-Peng He*, Tony D James*. The development of a novel AND logic based fluorescence probe for the detection of peroxynitrite and GSH. Chemical Science. 2018, 9: (15), 3672-3676. 

13.Changzheng Wang#, Hai-Hao Han#, Xinying Tang, Dongming Zhou*, Changfeng Wu, Guorong Chen, Xiao-Peng He*, He Tian. Sialylglycan-assembled supra-dots for ratiometric probing and blocking of human-infecting influenza viruses. ACS Applied Materials & Interfaces. 2017, 9: (30), 25164-25170. 

14.Wei-Tao Dou#, Hai-Hao Han#, Adam C.Sedgwick, Guo-Biao Zhu, Yi Zang, Xin-Rong Yang*, Juyoung Yoon*, Tony D. James*, Jia Li*, Xiao-Peng He*. Fluorescent probes for the detection of disease-associated biomarkers. Science Bulletin. 2022, 67, 853-878. 

15.Maria Weber#, Hai-Hao Han#, Bo-Han Li#, Maria L. Odyniec, Charlotte E. F. Jarman, Yi Zang, Steven D. Bull, Amanda B. Mackenzie, Adam C. Sedgwick*, Jia Li*, Xiao-Peng He*, Tony D. James*. Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications. Chemical Science. 2020, 11: (32), 8567-8571. 

16.Lei Dong#, Min-Yu Zhang#, Hai-Hao Han#, Yi Zang, Guo-Rong Chen, Jia Li*, Xiao-Peng He*, Sébastien Vidal*. A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters. Chemical Science. 2022, 13: (1), 247-256. 

17.He Tian Jr.#, Adam C. Sedgwick#, Hai-Hao Han#, Sajal Sen, Guo-Rong Chen, Yi Zang, Jonathan L. Sessler*, Tony D. James*, Jia Li*, Xiao-Peng He*. Fluorescent probes for the imaging of lipid droplets in live cells. Coordination Chemistry Reviews. 2021, 427, 213577.

18.Yueci Wu#, Hai-Hao Han#, Liu He, Li Li, Yi Zang, Jia Li*, Xiao-Peng He*, Yaping Ding*, Weiguo Cao*, Tony D James*. Selective detection of peroxynitrite using an isatin receptor and a naphthalimide fluorophore. Chemical Communications. 2023, 59: (34), 5051-5054.

社会任职

1.中国化学会会员

2.《iRADIOLOGY》创刊(Wiley出版)青年编委

3.《Frontier in Chemistry》期刊评审编辑(Review Editor)

4.英国皇家化学会国际期刊同行评议员