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药理学

谢欣

姓 名 谢欣 性 别 职 称 研究员、博导
学 历 博士 电 话 传 真
电子邮件 xxie@simm.ac.cn 个人主页 主页链接 专家类别
职 务 课题组长、博导
通讯地址 烟台市高新区滨海东路198号
个人简介

谢欣,现任中国科学院上海药物研究所/中科环渤海(烟台)药物高等研究院研究员,课题组长, 杰出青年基金获得者,两任973首席科学家。 新药筛选中心副主任,中科院受体结构与功能重点实验室副主任,上海科技大学生命科学与技术学院及国科大杭州高等研究院特聘教授。1996年毕业于北京大学化学系,获理学学士学位。2002年获得美国新泽西医科和牙科大学神经科学专业的博士学位。

工作经历

    2022.10-至今

    中科环渤海(烟台)药物高等研究院,课题组长、研究员

    2005.12-至今

    中国科学院上海药物研究所,研究员、课题组长

    2004.05-至今

    新药筛选中心,历任模型建立II部主管、 副主任  

    2003.07-2004.05

    信谊药厂药物研究所,对外合作部主任

    2002.05-2003.06

    美国新泽西医科和牙科大学神经科学系,博士后


     
     
     
     
研究方向

1.G蛋白偶联受体(GPCR)信号通路与重大疾病(自身免疫病,代谢性疾病,肿瘤等)相关性研究及基于GPCR的新药研发 

2.小分子化合物调控干细胞命运的研究及新药研发(小分子诱导体内细胞重编程及转分化)


科研项目

    2022-2026

    基金委创新群体,G蛋白偶联受体结构药理学,项目负责人

    2018-2022

    基金委重点项目,中链脂肪酸受体作为抗炎症性肠病药物作用新靶点的研究,项目负责人

    2015-2019

    科技部干细胞研究重大科学研究计划,小分子药物调控细胞命运及其机理研究,首席科学


科研成果

长期从事基于G蛋白偶联受体(GPCR)和干细胞的重大疾病新机制、药物作用新靶点及生物活性新分子研究。其研究策略新颖,采用化学生物学和分子生物学结合的研究手段,利用老药、天然产物和特色小分子探针推进新靶点/新机制的研究,而其中发现的新活性分子一方面可作为工具药继续推进重大疾病的新机制研究,另一方面可以向药物先导化合物转化。近年来,谢欣课题组发现数个GPCR(CysLT1,A2B和KOR)是治疗自身免疫性疾病多发性硬化症(MS)的潜在药靶,揭示数个老药可有效控制MS,并提出免疫抑制和髓鞘再生的联合策略是治疗这类复杂疾病的新思路。在化学诱导体细胞重编程方面,在国际上 实现全化学诱导小鼠体内原位非心肌细胞向心肌细胞的重编程,并实现功能性修复。实验室也是国际上少数能实现全化学诱导iPS的实验室之一,为化学诱导体细胞重编程其在药物研发领域的应用提出新概念新方法。迄今已在Nature,Cell Research,Nature Communications,PNAS 等知名学刊上发表论文100余篇,他引>2500次;申请发明专利30余项,获授权10余项。作为主要发明人研发的靶向GPCR的抗前列腺增生1.1类新药DC042已获得临床研究批件,并实现成果转让。

荣誉获奖

    2019年 中国青年科技奖

    2017年 全国三八红旗手

    2013年 第十届中国青年女科学家奖 

    2012年 享受国务院政府特殊津贴专家 

    2012年 第六届上海青年科技英才提名奖 

    2012年 第六届药明康德生命化学学者奖  

    2012年 中科院上海分院系统杰出青年科技创新人才  

    2009年 新世纪百千万人才工程 人选


代表论著

      1.Peiyu Xu, Sijie Huang, Shimeng Guo, Ying Yun, Xi Cheng, Xinheng He, Pengjun Cai, Yuan Lan, Hu Zhou, Hualiang Jiang, Yi Jiang*, Xin Xie*, H. Eric Xu*. Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nature Structural & Molecular Biology. 2022 Aug 15. doi: 10.1038/s41594-022-00816-5. Online ahead of print.

      2.Ren Guo, Xiaohui Jia, Zhenbin Ding, Gang Wang, Mengmeng Jiang, Bing Li, Shanshan Chen, Bingqing Xia, Qing Zhang, Jian Liu, Ruting Zheng, Zhaobing Gao, Xin Xie*. Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation. Theranostics. 2022, 12(11): 5220-5236. doi: 10.7150/thno.71400 

      3.Suo N, He B, Cui S, Yang Y, Wang M, Yuan Q, Xie X*. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. Glia. 2022 Jun 27. doi: 10.1002/glia.24233. Online ahead of print.

      4.Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H*, Zhang Y*, Xie X*, Jiang Y*. Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. Nat Commun. 2022 Mar 15;13(1):1364.

      5.Chen LH, Zhang Q, Xiao YF, Fang YC, Xie X*, Nan FJ*. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem. 2022 Mar 10;65(5):3991-4006. doi: 10.1021/acs.jmedchem.1c01813. Epub 2022 Feb 23.

      6.Qing Zhang#, Linhai Chen#, Hui Yang#, Youchen Fang, Siwei Wang, Min Wang, Qianting Yuan, Wei Wu, Yangming Zhang, Zhanju Liu*, Fajun Nan*, Xin Xie*. GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages. Acta Pharmacologica Sinica, 2022 Aug;43(8):2042-2054. doi: 10.1038/s41401-021-00825-y. Epub 2021 Dec 15.

      7.Yun Y, Zhang C, Guo S, Liang X, Lan Y, Wang M, Zhuo N, Yin J, Liu H, Gu M, Li J, Xie X*, Nan F*. Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5 H88Y Mutant Mice. J Med Chem. 2021 Aug 26;64(16):12181-12199.

      8.Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE*, Xie X*, Jiang Y*. Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun. 2021 Aug 20;12(1):5064.

      9.Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP*, Xie X*, Yu X*, Zhang Y*. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Jul 22. doi: 10.1038/s41586-020-2569-1.

      10.Na Suo, Yu-e Guo, Bingqing He, Haifeng Gu, Xin Xie*. Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia, 2019 Jul;67(7):1320-1332.

      11.Chenwen Huang, Wanzhi Tu, Yanbin Fu, Xin Xie*. Chemical-induced cardiac reprogramming in vivo. Cell Research, 2018 Jun;28(6):686-689.

      12.Haikun Song, Hexuan Li, Shimeng Guo, Yuyin Pan, Yuhua Fu, Zijian Zhou, Zhaoyang Li, Xue Wen, Xiaoli Sun, Bingqing He, Haifeng Gu, Youhong Hu, Xin Xie*, Boxun Lu*. Targeting Gpr52 Lowers Mutant HTT Levels and Rescues Huntington’s Disease-associated Phenotypes. Brain, 2018 Jun 1;141(6):1782-1798.

      13.Ren Guo, Wei Tang, Qianting Yuan, Lijian Hui, Xin Wang, Xin Xie*. Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription Factor, Stem Cell Reports, 2017, Aug 8;9(2):499-512.

      14.Jiali Jin, Jian Liu, Cong Chen, Zhenping Liu, Cong Jiang, Hongshang Chu, Weijuan Pan, Xinbo Wang, Lingqiang Zhang, Bin Li, Cizhong Jiang, Xin Ge, Xin Xie*, Ping Wang*. The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nature Communications, 2016 Nov 25;7:13594.

      15.Changsheng Du, Yanhui Duan, Hui Chai, Yingying Cai, Wei Wei, Jie Lv, Xin Xie*. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.Nature Communications, 2016 Apr 4;7:11120.

      16.Yuan Long, Min Wang, Haifeng Gu, Xin Xie*. Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells. Cell Research, 2015 Oct;25(10):1171-4.

      17.Yanbin Fu, Chenwen Huang, Xinxiu Xu, Haifeng Gu, Youqiong Ye, Cizhong Jiang, Zilong Qiu, Xin Xie*. Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. Cell Research, 2015 Sep;25(9):1013-24.

      18.Kong X, Liu J, Li L, Yue L, Zhang L, Jiang H, Xie X*, Luo C*. Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition. Nucleic Acids Research, 2015 May 19; 43(9):4381-92.

      19.Shuyong Zhang, Yuyong Ma, Jing Li, Biao Yu*, Xin Xie*. Molecular matchmaking between the popular ‘weight loss’ herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorders. Proc Natl Acad Sci U S A, 2014 Oct 7;111(40):14571-6.

      20.Guofang Chen, Xinxiu Xu, Lihong Zhang, Yanbin Fu, Min Wang, Haifeng Gu, Xin Xie*. Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cells self-renewal and somatic cell reprogramming. Cell Research, 2014 Sep;24(9):1121-36.

      21.Xiaoyuan Wei, Yueting Chen, Yongyu Xu, Yang Zan, Ru Zhang, Min Wang, Qiuhong Hua, Haifeng Gu, Fajun Nan*, Xin Xie*. Small molecule compound induces chromatin de-condensation and facilitate induced pluripotent stem cell generation. Journal of Molecular Cell Biology, 2014 Oct;6(5):409-20.

      22.Yongyu Xu, Xiaoyuan Wei, Min Wang, Ru Zhang*, Yanbin Fu, Mingzhe Xing, Qiuhong Hua, Xin Xie*. Proliferation rate of somatic cells affects reprogramming efficiency. Journal of Biological Chemistry. 2013, Apr 5;288(14):9767-78.

      23.Feifei Zhang, Wei Wei, Hui Chai, Xin Xie*. Aurintricarboxylic Acid Ameliorates Experimental Autoimmune Encephalomyelitis by Blocking Chemokine-mediated Pathogenic Cell Migration and Infiltration. Journal of Immunology. 2013 Feb 1;190(3):1017-25.

      24.Wei Wei, Changsheng Du, Jie Lv, Guixian Zhao, Zhenxin Li, Zhiying Wu, G Haskó, Xin Xie*. Blocking A2B Adenosine Receptor alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis via Inhibition of IL-6 Production and TH-17 Differentiation. Journal of Immunology. 2013 Jan 1;190(1):138-46.

      25.Xinxiu Xu, Quan Wang, Yuan Long, Ru Zhang, Xiaoyuan Wei, Mingzhe Xing, Haifeng Gu, Xin Xie*. Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Research. 2013 Jan;23(1):131-41.

      26.Jie Lv, Changsheng Du, Wei Wei, Zhiying Wu, Guixian Zhao, Zhenxin Li, Xin Xie*. The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis. Journal of Biological Chemistry.2012 Aug 17; 287(34):28656-65.

      27.Chang-Sheng Du, Xin Xie*. G Protein-Coupled Receptors as Therapeutic Targets for Multiple Sclerosis. Cell Research. 2012 Jul; 22(7):1108-28.

      28.Liefeng Wang, Changsheng Du, Jie Lv, Wei Wei, Ye Cui, Xin Xie*. Antiasthmatic Drugs Targeting the Cysteinyl Leukotriene Receptor 1 Alleviate Central Nervous System Inflammatory Cell Infiltration and Pathogenesis of Experimental Autoimmune Encephalomyelitis. Journal of Immunology. 2011;187(5):2336-45.

      29.Quan Wang, Xinxiu Xu, Jun Li, Jing Liu, Haifeng Gu, Ru Zhang, Jiekai Chen, Yin Kuang, Jian Fei, Cong Jiang, Ping Wang, Duanqing Pei, Sheng Ding, Xin Xie*. Lithium, an anti-Psychotic Drug, Greatly Enhances the Generation of Induced Pluripotent Stem Cells. Cell Research. 2011;21(10):1424-35.

      30.He X, Fang L, Wang J, Yi Y, Zhang S, Xie X*. Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Research 2008 Nov 1; 68(21):8678-86. 


社会任职

2008.12-至今  Acta Pharmacologica Sinica编委

2014.05-至今  中国细胞生物学学会干细胞生物学分会,委员

2018-至今  上海市药理学会,委员


谢欣

姓 名 谢欣 性 别 职 称 研究员、博导
学 历 博士 电 话 传 真
电子邮件 xxie@simm.ac.cn 个人主页 主页链接 专家类别
职 务 课题组长、博导
通讯地址 烟台市高新区滨海东路198号
个人简介

    谢欣,现任中国科学院上海药物研究所/中科环渤海(烟台)药物高等研究院研究员,课题组长, 杰出青年基金获得者,两任973首席科学家。 新药筛选中心副主任,中科院受体结构与功能重点实验室副主任,上海科技大学生命科学与技术学院及国科大杭州高等研究院特聘教授。1996年毕业于北京大学化学系,获理学学士学位。2002年获得美国新泽西医科和牙科大学神经科学专业的博士学位。

工作经历

    2022.10-至今

    中科环渤海(烟台)药物高等研究院,课题组长、研究员

    2005.12-至今

    中国科学院上海药物研究所,研究员、课题组长

    2004.05-至今

    新药筛选中心,历任模型建立II部主管、 副主任  

    2003.07-2004.05

    信谊药厂药物研究所,对外合作部主任

    2002.05-2003.06

    美国新泽西医科和牙科大学神经科学系,博士后


     
     
     
     
研究方向

    1.G蛋白偶联受体(GPCR)信号通路与重大疾病(自身免疫病,代谢性疾病,肿瘤等)相关性研究及基于GPCR的新药研发 

    2.小分子化合物调控干细胞命运的研究及新药研发(小分子诱导体内细胞重编程及转分化)


科研项目

    2022-2026

    基金委创新群体,G蛋白偶联受体结构药理学,项目负责人

    2018-2022

    基金委重点项目,中链脂肪酸受体作为抗炎症性肠病药物作用新靶点的研究,项目负责人

    2015-2019

    科技部干细胞研究重大科学研究计划,小分子药物调控细胞命运及其机理研究,首席科学


科研成果

    长期从事基于G蛋白偶联受体(GPCR)和干细胞的重大疾病新机制、药物作用新靶点及生物活性新分子研究。其研究策略新颖,采用化学生物学和分子生物学结合的研究手段,利用老药、天然产物和特色小分子探针推进新靶点/新机制的研究,而其中发现的新活性分子一方面可作为工具药继续推进重大疾病的新机制研究,另一方面可以向药物先导化合物转化。近年来,谢欣课题组发现数个GPCR(CysLT1,A2B和KOR)是治疗自身免疫性疾病多发性硬化症(MS)的潜在药靶,揭示数个老药可有效控制MS,并提出免疫抑制和髓鞘再生的联合策略是治疗这类复杂疾病的新思路。在化学诱导体细胞重编程方面,在国际上 实现全化学诱导小鼠体内原位非心肌细胞向心肌细胞的重编程,并实现功能性修复。实验室也是国际上少数能实现全化学诱导iPS的实验室之一,为化学诱导体细胞重编程其在药物研发领域的应用提出新概念新方法。迄今已在Nature,Cell Research,Nature Communications,PNAS 等知名学刊上发表论文100余篇,他引>2500次;申请发明专利30余项,获授权10余项。作为主要发明人研发的靶向GPCR的抗前列腺增生1.1类新药DC042已获得临床研究批件,并实现成果转让。

荣誉获奖

    2019年 中国青年科技奖

    2017年 全国三八红旗手

    2013年 第十届中国青年女科学家奖 

    2012年 享受国务院政府特殊津贴专家 

    2012年 第六届上海青年科技英才提名奖 

    2012年 第六届药明康德生命化学学者奖  

    2012年 中科院上海分院系统杰出青年科技创新人才  

    2009年 新世纪百千万人才工程 人选


代表论著

    1.Peiyu Xu, Sijie Huang, Shimeng Guo, Ying Yun, Xi Cheng, Xinheng He, Pengjun Cai, Yuan Lan, Hu Zhou, Hualiang Jiang, Yi Jiang*, Xin Xie*, H. Eric Xu*. Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nature Structural & Molecular Biology. 2022 Aug 15. doi: 10.1038/s41594-022-00816-5. Online ahead of print.

    2.Ren Guo, Xiaohui Jia, Zhenbin Ding, Gang Wang, Mengmeng Jiang, Bing Li, Shanshan Chen, Bingqing Xia, Qing Zhang, Jian Liu, Ruting Zheng, Zhaobing Gao, Xin Xie*. Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation. Theranostics. 2022, 12(11): 5220-5236. doi: 10.7150/thno.71400 

    3.Suo N, He B, Cui S, Yang Y, Wang M, Yuan Q, Xie X*. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. Glia. 2022 Jun 27. doi: 10.1002/glia.24233. Online ahead of print.

    4.Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H*, Zhang Y*, Xie X*, Jiang Y*. Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. Nat Commun. 2022 Mar 15;13(1):1364.

    5.Chen LH, Zhang Q, Xiao YF, Fang YC, Xie X*, Nan FJ*. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem. 2022 Mar 10;65(5):3991-4006. doi: 10.1021/acs.jmedchem.1c01813. Epub 2022 Feb 23.

    6.Qing Zhang#, Linhai Chen#, Hui Yang#, Youchen Fang, Siwei Wang, Min Wang, Qianting Yuan, Wei Wu, Yangming Zhang, Zhanju Liu*, Fajun Nan*, Xin Xie*. GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages. Acta Pharmacologica Sinica, 2022 Aug;43(8):2042-2054. doi: 10.1038/s41401-021-00825-y. Epub 2021 Dec 15.

    7.Yun Y, Zhang C, Guo S, Liang X, Lan Y, Wang M, Zhuo N, Yin J, Liu H, Gu M, Li J, Xie X*, Nan F*. Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5 H88Y Mutant Mice. J Med Chem. 2021 Aug 26;64(16):12181-12199.

    8.Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE*, Xie X*, Jiang Y*. Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun. 2021 Aug 20;12(1):5064.

    9.Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP*, Xie X*, Yu X*, Zhang Y*. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Jul 22. doi: 10.1038/s41586-020-2569-1.

    10.Na Suo, Yu-e Guo, Bingqing He, Haifeng Gu, Xin Xie*. Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia, 2019 Jul;67(7):1320-1332.

    11.Chenwen Huang, Wanzhi Tu, Yanbin Fu, Xin Xie*. Chemical-induced cardiac reprogramming in vivo. Cell Research, 2018 Jun;28(6):686-689.

    12.Haikun Song, Hexuan Li, Shimeng Guo, Yuyin Pan, Yuhua Fu, Zijian Zhou, Zhaoyang Li, Xue Wen, Xiaoli Sun, Bingqing He, Haifeng Gu, Youhong Hu, Xin Xie*, Boxun Lu*. Targeting Gpr52 Lowers Mutant HTT Levels and Rescues Huntington’s Disease-associated Phenotypes. Brain, 2018 Jun 1;141(6):1782-1798.

    13.Ren Guo, Wei Tang, Qianting Yuan, Lijian Hui, Xin Wang, Xin Xie*. Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription Factor, Stem Cell Reports, 2017, Aug 8;9(2):499-512.

    14.Jiali Jin, Jian Liu, Cong Chen, Zhenping Liu, Cong Jiang, Hongshang Chu, Weijuan Pan, Xinbo Wang, Lingqiang Zhang, Bin Li, Cizhong Jiang, Xin Ge, Xin Xie*, Ping Wang*. The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nature Communications, 2016 Nov 25;7:13594.

    15.Changsheng Du, Yanhui Duan, Hui Chai, Yingying Cai, Wei Wei, Jie Lv, Xin Xie*. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.Nature Communications, 2016 Apr 4;7:11120.

    16.Yuan Long, Min Wang, Haifeng Gu, Xin Xie*. Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells. Cell Research, 2015 Oct;25(10):1171-4.

    17.Yanbin Fu, Chenwen Huang, Xinxiu Xu, Haifeng Gu, Youqiong Ye, Cizhong Jiang, Zilong Qiu, Xin Xie*. Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. Cell Research, 2015 Sep;25(9):1013-24.

    18.Kong X, Liu J, Li L, Yue L, Zhang L, Jiang H, Xie X*, Luo C*. Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition. Nucleic Acids Research, 2015 May 19; 43(9):4381-92.

    19.Shuyong Zhang, Yuyong Ma, Jing Li, Biao Yu*, Xin Xie*. Molecular matchmaking between the popular ‘weight loss’ herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorders. Proc Natl Acad Sci U S A, 2014 Oct 7;111(40):14571-6.

    20.Guofang Chen, Xinxiu Xu, Lihong Zhang, Yanbin Fu, Min Wang, Haifeng Gu, Xin Xie*. Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cells self-renewal and somatic cell reprogramming. Cell Research, 2014 Sep;24(9):1121-36.

    21.Xiaoyuan Wei, Yueting Chen, Yongyu Xu, Yang Zan, Ru Zhang, Min Wang, Qiuhong Hua, Haifeng Gu, Fajun Nan*, Xin Xie*. Small molecule compound induces chromatin de-condensation and facilitate induced pluripotent stem cell generation. Journal of Molecular Cell Biology, 2014 Oct;6(5):409-20.

    22.Yongyu Xu, Xiaoyuan Wei, Min Wang, Ru Zhang*, Yanbin Fu, Mingzhe Xing, Qiuhong Hua, Xin Xie*. Proliferation rate of somatic cells affects reprogramming efficiency. Journal of Biological Chemistry. 2013, Apr 5;288(14):9767-78.

    23.Feifei Zhang, Wei Wei, Hui Chai, Xin Xie*. Aurintricarboxylic Acid Ameliorates Experimental Autoimmune Encephalomyelitis by Blocking Chemokine-mediated Pathogenic Cell Migration and Infiltration. Journal of Immunology. 2013 Feb 1;190(3):1017-25.

    24.Wei Wei, Changsheng Du, Jie Lv, Guixian Zhao, Zhenxin Li, Zhiying Wu, G Haskó, Xin Xie*. Blocking A2B Adenosine Receptor alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis via Inhibition of IL-6 Production and TH-17 Differentiation. Journal of Immunology. 2013 Jan 1;190(1):138-46.

    25.Xinxiu Xu, Quan Wang, Yuan Long, Ru Zhang, Xiaoyuan Wei, Mingzhe Xing, Haifeng Gu, Xin Xie*. Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Research. 2013 Jan;23(1):131-41.

    26.Jie Lv, Changsheng Du, Wei Wei, Zhiying Wu, Guixian Zhao, Zhenxin Li, Xin Xie*. The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis. Journal of Biological Chemistry.2012 Aug 17; 287(34):28656-65.

    27.Chang-Sheng Du, Xin Xie*. G Protein-Coupled Receptors as Therapeutic Targets for Multiple Sclerosis. Cell Research. 2012 Jul; 22(7):1108-28.

    28.Liefeng Wang, Changsheng Du, Jie Lv, Wei Wei, Ye Cui, Xin Xie*. Antiasthmatic Drugs Targeting the Cysteinyl Leukotriene Receptor 1 Alleviate Central Nervous System Inflammatory Cell Infiltration and Pathogenesis of Experimental Autoimmune Encephalomyelitis. Journal of Immunology. 2011;187(5):2336-45.

    29.Quan Wang, Xinxiu Xu, Jun Li, Jing Liu, Haifeng Gu, Ru Zhang, Jiekai Chen, Yin Kuang, Jian Fei, Cong Jiang, Ping Wang, Duanqing Pei, Sheng Ding, Xin Xie*. Lithium, an anti-Psychotic Drug, Greatly Enhances the Generation of Induced Pluripotent Stem Cells. Cell Research. 2011;21(10):1424-35.

    30.He X, Fang L, Wang J, Yi Y, Zhang S, Xie X*. Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Research 2008 Nov 1; 68(21):8678-86. 


社会任职

2008.12-至今  Acta Pharmacologica Sinica编委

2014.05-至今  中国细胞生物学学会干细胞生物学分会,委员

2018-至今  上海市药理学会,委员